Expanding SolveEczema’s blog during the Covid-19 pandemic

Expanding SolveEczema’s blog during the Covid-19 pandemic

 

I have decided to expand the scope of my posts during the pandemic, to include a backlog of SolveEczema-related updates, but also education—my son is now going off to college—environmental health, and other problems that need attention since national news is so focused, necessarily, on the pandemic. Some things need to be said, that aren’t being said.

It may seem as if my blog hasn’t been active, and but I have had to focus on behind-the-scenes stuff like moving my website to a new host and all the nail-biting and nested-tech-tasks-of-indeterminate-time-sinks that entailed. I’m very thankful the new host seems to be so much better.

My son ended up homeschooling for high school, to start in large part because our local school didn’t handle either the environmental health issues or his education very well. I have a lot to share about how families can hopefully be more successful than we were at improving their schools’ environmental health.

It’s become more imperative because environmental health research shows that when schools are closed up for any period of time, as schools all over the world are now because of the Covid-19 pandemic, the sudden worsening of indoor air quality from everything being stirred up when schools are reopened makes for a spike in colds, flus, and upper respiratory infections among students and staff. After everything everyone is doing to end this pandemic, the environmental health evidence-base points to the need to head off that surge by understanding effective indoor air quality management to avoid another round of lockdowns and a surge in the Covid-19 cases when schools and colleges start up again.

So, for the next few months, my posts won’t necessarily be on topic. I will try to make posts that are helpful my site users, since I want everyone to be able to safely employ preventive environmental strategies for eczema and asthma while also following CDC and other official guidelines and recommendations to stay safe.

Blessings and good health, everyone!

–AJ

How to Find the Detergents, Allergens, and Other Inert Ingredients in Medications

How to Find the Detergents, Allergens, and Other Inert Ingredients in Medications

Most medications are made up of the active ingredient — the medicine — and inert ingredients, such as dyes to help identify the medication.

Assorted Medications

Photo by NIAID – Assorted Medications, CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=62117217

Medications can contain Sodium Lauryl Sulfate (SLS) and other detergents. They can also contain other substances people are frequently allergic to, like dyes. Talc is another frequent ingredient, despite credible concerns and ongoing questions about its possible link to certain cancers. Yet other ingredients can have side effects, for example, sugar alcohols (sugar substitutes) like sorbitol can cause dizziness if taken regularly.

As this news story from CBS New York about inert ingredients and medications reports: “Millions of people think they’re allergic to life-saving medications like penicillin, but a recent study found that 90 percent of those folks … may be reacting [instead] to some of the inactive ingredients in the pills.”

The story points out the difficulties of finding the inert ingredients list because there are no labeling laws like there are for foods. It is currently far easier to find the list of ingredients in a box of breakfast cereal than it is for medications people take daily.

I recently needed to find a generic version of a medication I was using, and was frustrated by how difficult it was to find the inert ingredients. I eventually found a resource online through the NIH that seems to be about the best resource for identifying inert ingredients, Daily Med. The website contains over 100,000 drug listings.

You can search through its database of medications, and the site will display a list that includes the name of the drug, the manufacturer or packager, and the NDC code for the drug. The links go to pages that include a wealth of information: contraindications, indications of use, drug interactions, and much more, including — always at the very bottom — a link to the Ingredients and Appearance, and often a link to an image of the medication’s label.

Many drugs have different inert ingredients from one generic to the next, and from one dosage from the same manufacturer to the next, so to look up the exact drug to find its inert ingredients, scroll through the dosages on the Ingredients page to find the exact one you are using.

For SolveEczema.org users, being able to ensure medications taken daily are detergent-free can be a real challenge. I think it’s very important that site users prioritize the medications they need and that their doctors recommend, and NOT stop anything just because it has detergents in it, rather, discuss the situation with your MD before making changes. Having information means it might be possible to find non-detergent alternatives through the Daily Med site, and your doctor or pharmacy may be able to specify the one with the most tolerable inert ingredients or even prescribe a compounded version.

The CBS New York story suggests people may need to use a compounding pharmacy if they need medications without some of the inert ingredients. Which is, of course, it’s own endeavor, to find an affordable compounding pharmacy with a good track record for safety. Compounded medications tend to be very costly, and insurance may balk at paying.

There doesn’t seem to be a great deal of awareness about the issue of allergy and sensitivity to the inert ingredients in medications yet. At least the NIH Daily Med site has been very helpful to determine which versions of medications don’t contain SLS.

A SolveEczema Perspective: “The Cure for Dishpan Hands”  – Part 1

A SolveEczema Perspective: “The Cure for Dishpan Hands” – Part 1

Over the years, I have been thanked by many people who used SolveEczema.org just to solve a dry skin problem, even if they did not have eczema. I have been thanked by many parents and more than one doctor who realized they could wash their hands frequently when necessary, without drying their skin out. As I am very clear about on my website, I am not a doctor, this is based on my own personal observation and research. Getting results relies on capitalizing on that new perspective, so it is essential to understand that new perspective first.  (I also fundamentally approach things from a Safety First standpoint — I will never suggest doing anything in a way that should make anything worse, or that has to be “toughed out,” so it’s important to understand first AND always keep a doctor in the loop even if they don’t know the site, in case the unexpected happens.)

I am writing this to share what we — and now many others — have done using the Solveczema.org perspective to get unexpected, out-of-the-box results with ameliorating dry skin, for those who maybe can’t seem to find any moisturizing cream thick enough to prevent painful cracked skin during the winter or on travel, or who struggle with washing the dishes even with gloves.

Obviously, I can’t promise a “cure” without a traditional medical study, the title above is just a restatement of the usual idiom and my opinion about its applicability, although this is a perfect set up for a clinical study. I believe this perspective could not only improve the health of health providers’ skin, but also improve compliance with handwashing, and thus help reduce hospital-borne infection.

If you are ready to try this, first read the SolveEczema site disclaimer, watch the SolveEczema site video linked from the home page (note, I made it for a long-concluded crowdfunding for my book and haven’t been able to update the ending, it’s an amateur effort — sorry, it puts me to sleep, too — but it’s only about 45 minutes and is still a good summary of the site).  Read everything here, use your judgment, talk with your physician as needed for health and safety issues, and don’t make any changes until you understand how different this is.  It’s not about individual products, it’s about learning how to have optimal skin health without treatments or moisturizing, by understanding what, in my observation, is really going on.

I need to mention here again an open source paper I posted online about SolveEczema, giving a rough description of how it relates to the eczema and allergy epidemic of recent decades, and summarizing many of the novel observations:  https://thewinnower.com/papers/3412-abnormal-ampli-fication-observations-from-applying-the-engineering-method-to-solving-eczema-and-atopic-disease

It’s only two pages — please refer to the Analysis and Observations section for essential novel observations.

Again, with my apologies for the presumption of giving this a personal, alliterative name like this in hopes of making it more memorable, I also need to restate this very different-from-traditional view of why skin becomes dry after washing, per my own observations, because it’s crucial for getting results:

Photo of bar soap on soap tray

Lumsdaine’s Law: For most people, under most conditions, eczema and dry skin are more the result of what is left on the skin than what is stripped from the skin by washing.

 

 

Photo of dry hand skin

Photo of dry hand courtesy of Wikimedia

Water alone on the skin increases the membrane permeability. Membrane permeability is basically just how easily certain substances — like water molecules — can pass through the membrane, from within and without.  If you wash your hands in the winter and don’t dry them well afterwards, your hands chap even if you only washed in water, because the water left on the skin increases the permeability and accelerates water loss.

Under normal conditions, the restoration of water in the skin is quite rapid; if someone washes and it takes days for the skin to rehydrate, my contention is that it’s because of what is on the skin in the meantime, not usually from what was stripped from the skin by normal washing. Detergents on the skin (see the paper) in combination with a small layer of water, including from sweat, dramatically increases permeability and subsequent water loss.

Continued in Part 2…

Don’t Forget the Soap:  A SolveEczema.org Perspective on “The Farm Effect” and Eczema

Don’t Forget the Soap: A SolveEczema.org Perspective on “The Farm Effect” and Eczema

Photo of a Cow in Switzerland

Swiss Cows

Until I can finish a book or publish papers, I really can’t do this topic justice. And I’m not really sure users of my site (SolveEczema.org) really need much explanation. Once people really read and understand the site, and put the strategies into practice, what I’m about to say is pretty obvious.

A lot has been written in recent years about the “Farm Effect” — an astute observation made by pioneering eczema/hygiene hypothesis researchers that people who live on farms tend to have less eczema than people who don’t. This led to speculation about whether the reason had to do with dirt or microorganism exposure.

While I am not discounting microbial involvement — please see SolveEczema.org discussions for a different take on probiotics and eczema, and the last part of this very short paper that I wrote https://thewinnower.com/papers/3412-abnormal-ampli-cation-observations-from-applying-the-engineering-method-to-solving-eczema-and-atopic-disease — I also think people are making this far too complicated (with far too much contradictory evidence that isn’t explained).

Take for example the popular interpretations of this well-done study from 2012:
http://www.jacionline.org/article/S0091-6749(12)00519-2/fulltext

Researchers found a far higher rate of allergy, asthma, and eczema among children aged 6-12 who were from families of Swiss non-farmers than Swiss farmers. They also found the Swiss farmers had a higher rate than Amish in the US (who tend to be farmers, though not all). Researchers may have chosen the comparison with Amish in the US because they originally came from Switzerland, and may be genetically similar, although the comparison would have been even more useful if they had also surveyed the Amish-like communities still in Switzerland.

http://www.reuters.com/article/us-kidsallergies-idUSBRE8431J920120504
“As for why the Amish kids have even lower allergy and asthma rates than the other farming kids, “that piece of the puzzle we really haven’t explained,” [Indiana allergist who treats Amish patients] Holbreich told Reuters Health.”

So, to summarize: The Amish had the lowest rates of allergy, asthma, and eczema. The Swiss farmers had less allergic diseases than non-farmer general population, but higher than the Amish. This relative difference was true also for allergic sensitization to various allergens on testing.

The significant difference between the Amish and the farm families suggests the need to consider other influences.

Swiss cows everywhere and up close in Switzerland

Swiss cows everywhere and up close in Switzerland

Additionally, Switzerland is such a small country where farming and the farming community is simply not that isolated from the rest of the nation. It’s nothing like the US where you might have to drive a hundred miles to see a cow (or a farmer).

Swiss horses in the path

Swiss horses in the path

While Switzerland is an extremely clean country, let’s face it, the dairy industry is pretty important — it’s hard not to notice that there are a great many animals and a great many flies because dairy is so well integrated into the landscape. I just can’t see making a strong case that any population is that well isolated from any other there microbially.

swiss goat

Swiss goats are everywhere, too.

But in terms of lifestyle, the general Swiss population of non-farmers is using the same kinds of new surfactants that everyone else in the industrialized world is using where eczema and asthma are so high. They spend more time in homes breathing the detergent “dust” from this use than do farmers, who spend more time outdoors.

Swiss farmers may or may not be using less of such products.  While I doubt they are making their own soap anymore — though I do not know — they do spend more time outdoors, away from breathing such dusts. Recall that these substances increase antigen penetration of membranes, including lung, i.e., to the immune system, it’s as if there is more allergen in the environment.

In the US, farming communities gave up making their own soap later than everyone else. In some farming communities, soapmaking remains a strong tradition. The Amish are one of those communities, probably the most significantly so. Although acceptance of the modern can vary among Amish communities, there is a strong tradition of soapmaking among the Amish. This essay about Amish life in the 19th century (search on the word “soap”)  describes the process.  While it can be truly difficult to get specific data, it’s very unlikely that this tradition has changed much, if at all.

This relatively new environmental factor — the use of these highly hydrophilic modern surfactants that I believe are amplifying “normal” allergic processes — has a much more consistent and close ecological link to allergy, asthma, and eczema increases than any of the other explanations, across time and geography. This factor should be included in these types of studies, because of the potential to reconcile so much seemingly contradictory evidence, not just when it comes to the “Farm Effect”, but also when it comes to the research on allergy and exposure to pets like dogs and cats (especially the contradictory evidence when it comes to cats), or studies of allergy in households that handwash versus dishwasher wash the dishes. Getting into details is a long discussion for another day. However, because these surfactants can so powerfully influence human membranes in a way that is known and directly speaks to allergy, I think it’s too bad the studies don’t include anything at all about this factor. Especially since, as in the study above, there is likely to be a big difference in usage between the populations.

The SolveEczema.org perspective reconciles the major inconsistencies in the research of most of these different factors, such as the Farm Effect. And the SolveEczema.org strategies, from experience, happen to lead to dramatic reduction of asthma and allergies in concert with eczema amelioration, not just for the child with eczema, but everyone in the household. And it doesn’t require getting dirty or rolling around in cow or horse … um … microbes.

 

This room was one part of a structure also housing a mountain café, where day hikers frequently stop for tea or hot cocoa. Note the nearly brand new calf.

This room was one part of a structure also housing a mountain café, where day hikers frequently stop for tea or hot cocoa. Note the nearly brand new calf.  OK – this isn’t a common sight in Switzerland – but cows (and their microbes) are.

SolveEczema News and Publication

SolveEczema News and Publication

One of the goals when I started to write a book about SolveEczema.org (still in the works!) was to find a way to bring the ideas into a mainstream medical and scientific forum for discussion and validation, including also writing a scientific paper. After years considering how to publish something so different, I published in a new open source platform called The Winnower, which offers post-publication peer review.

You can view the paper at: https://thewinnower.com/papers/3412-abnormal-ampli-fication-observations-from-applying-the-engineering-method-to-solving-eczema-and-atopic-disease

I know this probably sounds very dry to site users, but for anyone who has asked the question “Why didn’t my doctor give me this information?!” (too many to count have emailed me the same question), you may be interested in the scientific validation of this work, because it will mean other children will be spared the same suffering.  Although many doctors have used and referred SolveEczema.org to patients over the years, it will be tough to reach everyone or work on solving related health conditions without the validation of peer review.

I’m having some computer problems lately, so rather than trying to compose a post to explain, here are some edited excerpts from recent letters I wrote:
SolveEczema.org represents the novel application of modern technical problem solving, in particular, the engineering method, to solving a medical condition, eczema and related allergy. The engineering method has been described as “The use of heuristics to cause the best change in a poorly understood situation within the available resources.” (BV Koen, The Bent of Tau Beta Pi, 1985)

When an environmental cause underlies a medical condition, complex environmental and exposure differences can translate to seemingly intractable person-to-person variability. This work involves the unraveling of this seeming complexity by using heuristics that allow individuals to focus on controlling what’s important to problem solve in their own circumstances. The paper presents a number of insights that came about as part of the problem solving process and subsequent research, such as why a key aspect of the solution has been overlooked to date and why a new approach is needed for the validation of heuristic solutions.

A letter to a doctor who expressed an interest in a collaboration:
The article mentions how this perspective could reconcile seemingly contradictory hygiene hypothesis research. For example, for awhile, researchers said owning dogs and cats was protective, then they said it was just dogs, etc. The issue the research didn’t take into account was developments in cleaning equipment (e.g. better, filtered vacs, and more frequent cleaning of pet hair), and the fact that cats use cat litter which is just loaded with detergents that they track through homes. Birth order – anyone with a first child with allergies is going to make changes in the home environment and products, which are bound to be preventive for the later children, also never taken into account. Breastfeeding and allergies, too – the studies used to show a protective effect, then later studies said no.  I think both are probably right (the later studies looked at older children, where detergents were by then probably a more significant influence).

And (same person):

You are spot on about related health issues. I think ultimately this issue is as major an environmental problem as smoking was, in some ways worse because other creatures in the environment are affected. (I think it’s highly likely that frogs, bats, and honeybees, possibly even otters, may be experiencing serious unrecognized harm, but that’s another discussion.) Asthma, allergies, dry skin, and even wrinkles are major related issues. I have been surprised at how much the changes markedly decreased the propensity for sunburn (which could have a major impact downstream on skin cancer). Over the years, I have been thanked on several occasions by doctors specifically over the issue of having good skin despite constant handwashing – perhaps that’s something we could collaborate over. The physician handwashing issue touches on many health problems: hospital-borne infection, possible improving willingness to wash hands over using sanitizers (which is probably healthier for providers who don’t absorb so much through their skin, and reducing infections since washing is better than sanitizers), maintaining a better barrier on providers’ hands to reduce the harboring of microbes, possibly reducing the general need for antimicrobial chemicals in handwashes in some settings if mechanical means are less damaging (reducing development of resistant strains), etc.

I have been thinking a lot lately about whether it would be possible to design a case-control study. Unfortunately, the barrier is that the engineering method relies on heuristics – when an environmental cause underlies a disease, unless it is very simple to remove the cause, there is no way to apply a completely controlled treatment or course of anything. To solve the problem in every individual case, it’s necessary for people to use a heuristic tool to apply the solution in the best way for their individual environmental exposures, health status, genetic profile, etc. Then the concern is how well each person uses the heuristic tool versus how well the tool works for them. Additionally, with the engineering method, it wouldn’t make sense to apply the tool exactly the same for everyone, then judge what percentage were helped – the whole point of it is that if one case isn’t solved 100%, the unresolved case doesn’t become data, it becomes a resource to revise the heuristic tool to encompass new information to achieve the same standard of outcome or solution for that person and everyone.

That isn’t a problem-solving approach currently in use in medicine, and it clashes with normal epidemiological methods. The method itself would have to be the subject of peer review, in the context of a solution like this being peer reviewed. Just yesterday I heard an oncologist (The Death of Cancer) speak on the radio about how “regulations” were keeping him from solving problems for individual cancer patients. The ideal he described, what he really wanted to do, was really the engineering method. I think some doctors are using heuristics in other areas of medicine because they get better outcomes for their patients, and the lack of overt discussion of heuristics is, IMO, causing some of the bigger medical controversies of our time. Finding a way to ethically, with all the right safeguards, incorporate the engineering method into medicine, I believe could result in many currently unsolved disease problems being solved. No new scientific or medical breakthroughs are needed, just problem solving we already know how to do in other technical arenas.
—

Validating the site work – peer review is a start – would prove eczema and atopy are solvable problems, on an individual and general disease problem level.  That sounds simple, yet it’s an earth-shattering idea.  Believe it or not, the biggest challenge here is overcoming the idea, the really hard-ingrained prejudice, that a major, complex, seemingly intractable medical problem could even possibly be solved.

So, yes, finding a route to peer-review and publication has been challenging (ironically more challenging than solving my child’s severe eczema and helping thousands around the world do the same over the past >10 years).  You can view the paper at: https://thewinnower.com/papers/3412-abnormal-ampli-fication-observations-from-applying-the-engineering-method-to-solving-eczema-and-atopic-disease